Article
Mechanochemical consequences of myopathy-linked mutations in Tpm2.2 on striated muscle contractility.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jan 2024
Küçükdogru Recep, Franz Peter, Worch Remigiusz, Robaszkiewicz Katarzyna, Siatkowska Małgorzata, Tsiavaliaris Georgios, Moraczewska Joanna
Abstract excerpt
Tropomyosin (Tpm) is an actin-binding protein central to muscle contraction regulation. The Tpm sequence consists of periodic repeats corresponding to seven actin-binding sites, further divided in two functionally distinct halves. To clarify the importance of the first and second halves of the actin-binding periods in regulating the interaction of myosin with actin, we introduced hypercontractile mutations D20H,...
Topics
- Actins
- Muscle, Skeletal
- Muscular Diseases
- Mutation
- Myosins
- Tropomyosin
- Animals