Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Arthritis in mice that are deficient in interleukin-1 receptor antagonist is dependent on genetic background.

Arthritis and rheumatism - 1 Dec 2005

Zhou Fang, He Xiaowen, Iwakura Yoichiro, Horai Reiko, Stuart John M

Abstract excerpt

OBJECTIVE: To determine the effect of deletion of interleukin-1 receptor antagonist (IL-1Ra) protein in an animal model of rheumatoid arthritis. METHODS: BALB/c mice deficient in IL-1Ra (IL-1Ra(-/-)) were bred with collagen-induced arthritis (CIA)-susceptible DBA/1 mice and B10 mice transgenic for HLA-DRB1*0101 (B10.DR1). After generation of IL-1Ra(-/-) mice on the DBA/1 and B10.DR1 backgrounds, the mice were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies
Share to Arthritis, Experimental
Share to CD3 Complex

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Collagen Type II

Share to Interleukin 1 Receptor Antagonist Protein

Share to Major Histocompatibility Complex

Share to Mice, Inbred DBA

Share to Sialoglycoproteins

Source

Identifiers

PMID: 16320323
DOI: 10.1002/art.21481

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Arthritis in mice that are deficient in interleukin-1 receptor antagonist is dependent on genetic background.PMID 16320323Read ↗

Altered susceptibility to collagen-induced arthritis in transgenic mice with aberrant expression of interleukin-1 receptor antagonist.Semantic proximity Read ↗

IL-10-deficient B10.Q mice develop more severe collagen-induced arthritis, but are protected from arthritis induced with anti-type II collagen antibodies.Semantic proximity Read ↗

Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA.Semantic proximity Read ↗

Congenic mice provide evidence for a genetic locus that modulates spontaneous arthritis caused by deficiency of IL-1RA.Semantic proximity Read ↗

Genetic ablation of interferon-gamma up-regulates interleukin-1beta expression and enables the elicitation of collagen-induced arthritis in a nonsusceptible mouse strain.Semantic proximity Read ↗

Collagen type II-specific monoclonal antibody-induced arthritis in mice: description of the disease and the influence of age, sex, and genes.Semantic proximity Read ↗

Psoriasis-like cutaneous inflammation in mice lacking interleukin-1 receptor antagonist.Semantic proximity Read ↗

Identification of genes controlling collagen-induced arthritis in mice: striking homology with susceptibility loci previously identified in the rat.Semantic proximity Read ↗

Characterization of T cell phenotype and function in a double transgenic (collagen-specific TCR/HLA-DR1) humanized model of arthritis.Semantic proximity Read ↗

CD28-dependent differentiation into the effector/memory phenotype is essential for induction of arthritis in interleukin-1 receptor antagonist-deficient mice.Semantic proximity Read ↗

Collagen-induced arthritis in C57BL/6 (H-2b) mice: new insights into an important disease model of rheumatoid arthritisSemantic proximity Read ↗

Analysis of candidate genes of spontaneous arthritis in mice deficient for interleukin-1 receptor antagonist.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.