Article
Detection and prognostic value of recurrent exportin 1 mutations in tumor and cell-free circulating DNA of patients with classical Hodgkin lymphoma.
Haematologica - 1 Sept 2016
Camus Vincent, Stamatoullas Aspasia, Mareschal Sylvain, Viailly Pierre-Julien, Sarafan-Vasseur Nasrin, Bohers Elodie, Dubois Sydney, Picquenot Jean Michel, Ruminy Philippe, Maingonnat Catherine, Bertrand Philippe, Cornic Marie, Tallon-Simon Valérie, Becker Stéphanie, Veresezan Liana, Frebourg Thierry, Vera Pierre, Bastard Christian, Tilly Hervé, Jardin Fabrice
Abstract excerpt
Classical Hodgkin lymphoma is one of the most common lymphomas and shares clinical and genetic features with primary mediastinal B-cell lymphoma. In this retrospective study, we analyzed the recurrent hotspot mutation of the exportin 1 (XPO1, p.E571K) gene, previously identified in primary mediastinal B-cell lymphoma, in biopsies and plasma circulating cell-free DNA from patients with classical Hodgkin lymphoma...
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