Article
Recurrent mutations of the exportin 1 gene (XPO1) and their impact on selective inhibitor of nuclear export compounds sensitivity in primary mediastinal B-cell lymphoma.
American journal of hematology - 1 Sept 2016
Jardin Fabrice, Pujals Anais, Pelletier Laura, Bohers Elodie, Camus Vincent, Mareschal Sylvain, Dubois Sydney, Sola Brigitte, Ochmann Marlène, Lemonnier François, Viailly Pierre-Julien, Bertrand Philippe, Maingonnat Catherine, Traverse-Glehen Alexandra, Gaulard Philippe, Damotte Diane, Delarue Richard, Haioun Corinne, Argueta Christian, Landesman Yosef, Salles Gilles, Jais Jean-Philippe, Figeac Martin, Copie-Bergman Christiane, Molina Thierry Jo, Picquenot Jean Michel, Cornic Marie, Fest Thierry, Milpied Noel, Lemasle Emilie, Stamatoullas Aspasia, Moeller Peter, Dyer Martin J S, Sundstrom Christer, Bastard Christian, Tilly Hervé, Leroy Karen
Abstract excerpt
Primary mediastinal B-cell lymphoma (PMBL) is an entity of B-cell lymphoma distinct from the other molecular subtypes of diffuse large B-cell lymphoma (DLBCL). We investigated the prevalence, specificity, and clinical relevance of mutations of XPO1, which encodes a member of the karyopherin-β nuclear transporters, in a large cohort of PMBL. PMBL cases defined histologically or by gene expression profiling (GEP)...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.