Digital PCR for quantification of recurrent and potentially actionable somatic mutations in circulating free DNA from patients with diffuse large B-cell lymphoma.

doi:10.3109/10428194.2016.1139703

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Article

Digital PCR for quantification of recurrent and potentially actionable somatic mutations in circulating free DNA from patients with diffuse large B-cell lymphoma.

Leukemia & lymphoma - 1 Sept 2016

Camus Vincent, Sarafan-Vasseur Nasrin, Bohers Elodie, Dubois Sydney, Mareschal Sylvain, Bertrand Philippe, Viailly Pierre-Julien, Ruminy Philippe, Maingonnat Catherine, Lemasle Emilie, Stamatoullas Aspasia, Picquenot Jean-Michel, Cornic Marie, Beaussire Ludivine, Bastard Christian, Frebourg Thierry, Tilly Hervé, Jardin Fabrice

Abstract excerpt

Diffuse large B-cell lymphoma (DLBCL) is an aggressive and heterogeneous malignancy harboring frequent targetable activating somatic mutations. Emerging evidence suggests that circulating cell-free DNA (cfDNA) can be used to detect somatic variants in DLBCL using Next-Generation Sequencing (NGS) experiments. In this proof-of-concept study, we chose to develop simple and valuable digital PCR (dPCR) assays for the...

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PMID: 26883583
DOI: 10.3109/10428194.2016.1139703

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