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Article

Astrocyte regional diversity in ALS includes distinct aberrant phenotypes with common and causal pathological processes.

Experimental cell research - 15 Oct 2020

Gomes Cátia, Sequeira Catarina, Barbosa Marta, Cunha Carolina, Vaz Ana Rita, Brites Dora

Abstract excerpt

Astrocytes are major contributors of motor neuron (MN) degeneration in amyotrophic lateral sclerosis (ALS). We investigated whether regional and cell maturation differences influence ALS astrocyte malfunction. Spinal and cortical astrocytes from SOD1G93A (mSOD1) 7-day-old mice were cultured for 5 and 13 days in vitro (DIV). Astrocyte aberrancies predominated in 13DIV cells with region specificity. 13DIV cortical...

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PMID: 32739211
DOI: 10.1016/j.yexcr.2020.112209

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