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Article

"Reprogram Enablement" as an Assay for Identifying Early Oncogenic Pathways by Their Ability to Allow Neoplastic Cells to Reacquire an Epiblast State.

Stem cell reports - 8 Sept 2020

Kong Yanjun, Gimple Ryan C, McVicar Rachael N, Hodges Andrew P, Yin Jun, Liu Yang, Zhan Weiwei, Snyder Evan Y

Abstract excerpt

One approach to understanding how tissue-specific cancers emerge is to determine the requirements for "reprograming" such neoplastic cells back to their developmentally normal primordial pre-malignant epiblast-like pluripotent state and then scrutinizing their spontaneous reconversion to a neoplasm, perhaps rendering salient the earliest pivotal oncogenic pathway(s) (before other aberrations accumulate in the...

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Identifiers

PMID: 32795421
DOI: 10.1016/j.stemcr.2020.07.016
PMCID: PMC7486218

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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