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Article

Reprogramming strategies for the establishment of novel human cancer models.

Cell cycle (Georgetown, Tex.) - 16 Sept 2016

Sancho-Martinez Ignacio, Izpisua Belmonte Juan Carlos

Abstract excerpt

Cancer comprises heterogeneous cells, ranging from highly proliferative immature precursors to more differentiated cell lineages. The emergence of the "cancer stem cell" (CSC) hypothesis that they are the cells responsible for resistance, metastasis and secondary tumor appearance identifies these populations as novel obligatory targets for the treatment of cancer. CSCs, like their normal tissue-specific stem cell...

Topics

Animals
Carcinogenesis
Cellular Reprogramming
Humans
Models, Biological
Mutation
Neoplasms
Neoplastic Stem Cells

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 27314153
DOI: 10.1080/15384101.2016.1196305
PMCID: PMC5026809

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