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Article

Connective tissue growth factor is critical for proper β-cell function and pregnancy-induced β-cell hyperplasia in adult mice.

American journal of physiology. Endocrinology and metabolism - 1 Sept 2016

Pasek Raymond C, Dunn Jennifer C, Elsakr Joseph M, Aramandla Mounika, Matta Anveetha R, Gannon Maureen

Abstract excerpt

During pregnancy, maternal β-cells undergo compensatory changes, including increased β-cell mass and enhanced glucose-stimulated insulin secretion. Failure of these adaptations to occur results in gestational diabetes mellitus. The secreted protein connective tissue growth factor (CTGF) is critical for normal β-cell development and promotes regeneration after partial β-cell ablation. During embryogenesis, CTGF is...

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Identifiers

PMID: 27460898
DOI: 10.1152/ajpendo.00194.2016
PMCID: PMC5142004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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