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Igf2 deletion alters mouse placenta endocrine capacity in a sexually dimorphic manner

7 May 2020

Abstract excerpt

The placenta regulates materno-fetal nutrient transfer and secretes hormones that enable maternal physiological support of the pregnancy. In mice, these functions are performed by the labyrinth (Lz) and junctional (Jz) zones, respectively. Insulin-like growth factor 2 (Igf2) is an imprinted gene expressed by the conceptus that is important for promoting fetal growth and placenta formation. However, the specific...

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PMID: 32380473
DOI: 10.1530/joe-20-0128

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