Article

Constitutive PDGFRb activation drives connective tissue overgrowth through STAT5-IGF1 signaling

2026-08-29

Abstract excerpt

Autosomal dominant gain-of-function mutations in platelet-derived growth factor receptor beta (PDGFRb) cause overgrowth of the skeleton and other connective tissue in Kosaki overgrowth syndrome. However, the target cell type and signaling pathways underlying PDGFRb-driven overgrowth are unknown. Normal postnatal growth is controlled by pituitary-secreted growth hormone (GH), which activates the STAT5 transcription...

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Literature Corpus work: df2aedde-0280-5105-8663-2a1e300a4bcd
DOI: 10.64898/2026.08.27.747555

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