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Article

Genetic variation in catechol-O-methyltransferase modifies effects of clonidine treatment in chronic fatigue syndrome.

The pharmacogenomics journal - 1 Oct 2016

Hall K T, Kossowsky J, Oberlander T F, Kaptchuk T J, Saul J P, Wyller V B, Fagermoen E, Sulheim D, Gjerstad J, Winger A, Mukamal K J

Abstract excerpt

Clonidine, an α2-adrenergic receptor agonist, decreases circulating norepinephrine and epinephrine, attenuating sympathetic activity. Although catechol-O-methyltransferase (COMT) metabolizes catecholamines, main effectors of sympathetic function, COMT genetic variation effects on clonidine treatment are unknown. Chronic fatigue syndrome (CFS) is hypothesized to result in part from dysregulated sympathetic...

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Identifiers

PMID: 27457818
DOI: 10.1038/tpj.2016.53
PMCID: PMC5028250

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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