Article
Evaluating the necessity of PCR duplicate removal from next-generation sequencing data and a comparison of approaches.
BMC bioinformatics - 25 Jul 2016
Ebbert Mark T W, Wadsworth Mark E, Staley Lyndsay A, Hoyt Kaitlyn L, Pickett Brandon, Miller Justin, Duce John, Kauwe John S K, Ridge Perry G
Abstract excerpt
BACKGROUND: Analyzing next-generation sequencing data is difficult because datasets are large, second generation sequencing platforms have high error rates, and because each position in the target genome (exome, transcriptome, etc.) is sequenced multiple times. Given these challenges, numerous bioinformatic algorithms have been developed to analyze these data. These algorithms aim to find an appropriate balance...
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