Article
Comparison of solution-based exome capture methods for next generation sequencing.
Genome biology - 28 Sept 2011
Sulonen Anna-Maija, Ellonen Pekka, Almusa Henrikki, Lepistö Maija, Eldfors Samuli, Hannula Sari, Miettinen Timo, Tyynismaa Henna, Salo Perttu, Heckman Caroline, Joensuu Heikki, Raivio Taneli, Suomalainen Anu, Saarela Janna
Abstract excerpt
BACKGROUND: Techniques enabling targeted re-sequencing of the protein coding sequences of the human genome on next generation sequencing instruments are of great interest. We conducted a systematic comparison of the solution-based exome capture kits provided by Agilent and Roche NimbleGen. A control DNA sample was captured with all four capture methods and prepared for Illumina GAII sequencing. Sequence data from...
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