Article
A novel approach for multi-SNP GWAS and its application in Alzheimer's disease.
BMC bioinformatics - 25 Jul 2016
Bodily Paul M, Fujimoto M Stanley, Page Justin T, Clement Mark J, Ebbert Mark T W, Ridge Perry G
Abstract excerpt
BACKGROUND: Genome-wide association studies (GWAS) have effectively identified genetic factors for many diseases. Many diseases, including Alzheimer's disease (AD), have epistatic causes, requiring more sophisticated analyses to identify groups of variants which together affect phenotype. RESULTS: Based on the GWAS statistical model, we developed a multi-SNP GWAS analysis to identify pairs of variants whose...
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