Article
Implication of the immune system in Alzheimer's disease: evidence from genome-wide pathway analysis.
Journal of Alzheimer's disease : JAD - 1 Jan 2010
Lambert Jean-Charles, Grenier-Boley Benjamin, Chouraki Vincent, Heath Simon, Zelenika Diana, Fievet Nathalie, Hannequin Didier, Pasquier Florence, Hanon Olivier, Brice Alexis, Epelbaum Jacques, Berr Claudine, Dartigues Jean-Francois, Tzourio Christophe, Campion Dominique, Lathrop Mark, Amouyel Philippe
Abstract excerpt
The results of several genome-wide association studies (GWASs) in the field of Alzheimer's disease (AD) have recently been published. Although these studies reported in detail on single-nucleotide polymorphisms (SNPs) and the neighboring genes with the strongest evidence of association with AD, little attention was paid to the rest of the genome. However, complementary statistical and bio-informatics approaches...
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