Discovery of gene-gene interactions across multiple independent data sets of late onset Alzheimer disease from the Alzheimer Disease Genetics Consortium.

doi:10.1016/j.neurobiolaging.2015.10.031

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Discovery of gene-gene interactions across multiple independent data sets of late onset Alzheimer disease from the Alzheimer Disease Genetics Consortium.

Neurobiology of aging - 1 Feb 2016

Hohman Timothy J, Bush William S, Jiang Lan, Brown-Gentry Kristin D, Torstenson Eric S, Dudek Scott M, Mukherjee Shubhabrata, Naj Adam, Kunkle Brian W, Ritchie Marylyn D, Martin Eden R, Schellenberg Gerard D, Mayeux Richard, Farrer Lindsay A, Pericak-Vance Margaret A, Haines Jonathan L, Thornton-Wells Tricia A

Abstract excerpt

Late-onset Alzheimer disease (AD) has a complex genetic etiology, involving locus heterogeneity, polygenic inheritance, and gene-gene interactions; however, the investigation of interactions in recent genome-wide association studies has been limited. We used a biological knowledge-driven approach to evaluate gene-gene interactions for consistency across 13 data sets from the Alzheimer Disease Genetics Consortium....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cadherin Related Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Calcium Channels, L-Type

Share to Datasets as Topic

Share to Receptors, Adrenergic, alpha-1

Share to Receptors, N-Methyl-D-Aspartate

Share to Ryanodine Receptor Calcium Release Channel

Share to Saposins

Share to Sirtuin 1

Source

Open in PubMed Open full text

Identifiers

PMID: 26827652
DOI: 10.1016/j.neurobiolaging.2015.10.031
PMCID: PMC4735733

Genes

ABCB1
SIRT1
CDH23
PEBP4
PSAP
RYR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Discovery of gene-gene interactions across multiple independent data sets of late onset Alzheimer disease from the Alzheimer Disease Genetics Consortium.PMID 26827652Read ↗

Manifestations of genetic risk for Alzheimer’s Disease in the blood: a cross-sectional multi-omic analysis in healthy adults aged 18-90+Semantic proximity Read ↗

Gene-Based Analysis in HRC Imputed Genome Wide Association Data Identifies Three Novel Genes For Alzheimer’s DiseaseSemantic proximity Read ↗

Integrative analysis of summary data from GWAS and eQTL studies implicates genes differentially expressed in Alzheimer's disease.Semantic proximity Read ↗

A <i>multiple-causal-gene-cluster</i> model underlying GWAS signals of Alzheimer’s diseaseSemantic proximity Read ↗

Assessment of the genetic variance of late-onset Alzheimer's disease.Semantic proximity Read ↗

Gene-based analysis in HRC imputed genome wide association data identifies three novel genes for Alzheimer's disease.Semantic proximity Read ↗

Genome-wide epistasis analysis for Alzheimer's disease and implications for genetic risk prediction.Semantic proximity Read ↗

Large multi-ethnic genetic analyses of amyloid imaging identify new genes for Alzheimer diseaseSemantic proximity Read ↗

Genome-wide interaction analysis of pathological hallmarks in Alzheimer's disease.Semantic proximity Read ↗

Association of Common and Rare Variants with Alzheimer’s Disease in over 13,000 Diverse Individuals with Whole-Genome Sequencing from the Alzheimer’s Disease Sequencing ProjectSemantic proximity Read ↗

Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E ϵ4,and the risk of late-onset Alzheimer disease in African Americans.Semantic proximity Read ↗

Genome-wide association studies of Alzheimer's disease and related disorders stratified by sex, onset age, and Apolipoprotein E genotype reveal novel risk loci in African Americans.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.