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Structural and evolutionary adaptation of rhoptry kinases and pseudokinases, a family of coccidian virulence factors

1 Jan 2013

Abstract excerpt

BACKGROUND: The widespread protozoan parasite Toxoplasma gondii interferes with host cell functions by exporting the contents of a unique apical organelle, the rhoptry. Among the mix of secreted proteins are an expanded, lineage-specific family of protein kinases termed rhoptry kinases (ROPKs), several of which have been shown to be key virulence factors, including the pseudokinase ROP5. The extent and details of...

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PMID: 23742205
DOI: 10.1186/1471-2148-13-117

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