Article
Heat-inducible degron and the making of conditional mutants.
Methods in enzymology - 1 Jan 2005
Dohmen R Jürgen, Varshavsky Alexander
Abstract excerpt
Conditional mutants retain the function of a specific gene under one set of conditions, called permissive, and lack that function under a different set of conditions, called nonpermissive; the latter must be still permissive for the wild-type allele of a gene. Such mutants make possible the analysis of physiological changes that follow controlled inactivation of a gene or gene product and can be used to address...
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