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Article

Dynamic evolution of hepatitis C virus resistance-associated substitutions in the absence of antiviral treatment.

Scientific reports - 31 Jan 2017

Eltahla Auda A, Leung Preston, Pirozyan Mehdi R, Rodrigo Chaturaka, Grebely Jason, Applegate Tanya, Maher Lisa, Luciani Fabio, Lloyd Andrew R, Bull Rowena A

Abstract excerpt

Resistance against new hepatitis C virus (HCV) antivirals is an area of increasing interest. Resistance-associated substitutions (RASs) have been identified in treatment-naïve individuals, but pressures driving treatment-independent RAS emergence are poorly understood. We analysed the longitudinal evolution of RASs in twelve participants with early acute HCV infections. Full-genome deep sequences were analysed...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28139734
DOI: 10.1038/srep41719
PMCID: PMC5282498

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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