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Article

Novel hepatitis B virus reverse transcriptase mutations in patients with sustained viremia despite long-term tenofovir treatment.

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 Jun 2022

Winckelmann Anni, Fahnøe Ulrik, Bajpai Priyanka Shukla, Dalegaard Magnus Illum, Lundh Andreas, Ryom Lene, Bukh Jens, Weis Nina

Abstract excerpt

BACKGROUND: Chronic hepatitis B virus (HBV) treatment consists of nucleos(t)ide analogues to suppress viral replication. The HBV inhibitor tenofovir has a high barrier to resistance, however, evidence of virus-escape is emerging. This study investigates HBV evolution in patients undergoing tenofovir treatment with the primary aim to assess the emergence of putative resistance mutations. METHODS: HBV DNA was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35487093
DOI: 10.1016/j.jcv.2022.105159

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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