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ptx3a+ fibroblast/epicardial cells provide a transient macrophage niche to promote heart regeneration

1 Apr 2024

Abstract excerpt

Macrophages conduct critical roles in heart repair, but the niche required to nurture and anchor them is poorly studied. Here, we investigated the macrophage niche in the regenerating heart. We analyzed cell-cell interactions through published single-cell RNA sequencing datasets and identified a strong interaction between fibroblast/epicardial (Fb/Epi) cells and macrophages. We further visualized the association...

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PMID: 38607913
DOI: 10.1016/j.celrep.2024.114092

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