Osteopontin, a Key Mediator Expressed by Senescent Pulmonary Vascular Cells in Pulmonary Hypertension.

doi:10.1161/ATVBAHA.116.307839

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Article

Osteopontin, a Key Mediator Expressed by Senescent Pulmonary Vascular Cells in Pulmonary Hypertension.

Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 2016

Saker Mirna, Lipskaia Larissa, Marcos Elisabeth, Abid Shariq, Parpaleix Aurelien, Houssaini Amal, Validire Pierre, Girard Philippe, Noureddine Hiba, Boyer Laurent, Vienney Nora, Amsellem Valerie, Marguerit Laurent, Maitre Bernard, Derumeaux Geneviève, Dubois-Rande Jean-Luc, Jourdan-Lesaux Claude, Delcroix Marion, Quarck Rozenn, Adnot Serge

Abstract excerpt

OBJECTIVE: Senescent pulmonary artery smooth muscle cells (PA-SMCs) may contribute to the pathogenesis of pulmonary hypertension by producing secreted factors. The aim of this study was to explore the role in pulmonary hypertension of extracellular matrix proteins released by senescent PA-SMCs. APPROACH AND RESULTS: Polymerase chain reaction array analysis of human PA-SMCs undergoing replicative senescence...

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PMID: 27444202
DOI: 10.1161/ATVBAHA.116.307839

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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