Extracellular matrix-associated molecules of senescent cells induce a senescence phenotype in proliferative cells via TGF-β signaling pathway.

Abstract excerpt

Senescent cells accumulate in various tissues as we age and are characterized by growth arrest and a senescence-associated secretory phenotype (SASP). This phenotype involves the release of various factors, such as pro-inflammatory molecules, reactive oxygen species (ROS) and extracellular vesicles (EVs), which can trigger senescence in neighboring cells. However, it remains unclear whether non-soluble factors...

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