Article

Endothelial cell senescence exacerbates pulmonary hypertension through Notch-mediated juxtacrine signaling

2021-02-02

Abstract excerpt

Pulmonary arterial hypertension (PAH) is a fatal disease characterized by pathological pulmonary artery remodeling. Endothelial cells (EC) injury including DNA damage is critically involved in the vascular remodeling in PAH, and persistent injury leads to cellular senescence in ECs. Here, we show that EC senescence exacerbates pulmonary hypertension through Notch-mediated juxtacrine signaling. EC-specific progeroi...

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Literature Corpus work: 909a8c07-611d-5595-95dc-73bffd0c1b2d
DOI: 10.1101/2021.02.02.429321

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