Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Natural Variant of the T Cell Receptor-Signaling Molecule Vav1 Reduces Both Effector T Cell Functions and Susceptibility to Neuroinflammation.

PLoS genetics - 1 Jul 2016

Kassem Sahar, Gaud Guillaume, Bernard Isabelle, Benamar Mehdi, Dejean Anne S, Liblau Roland, Fournié Gilbert J, Colacios Céline, Malissen Bernard, Saoudi Abdelhadi

Abstract excerpt

The guanine nucleotide exchange factor Vav1 is essential for transducing T cell antigen receptor signals and therefore plays an important role in T cell development and activation. Our previous genetic studies identified a locus on rat chromosome 9 that controls the susceptibility to neuroinflammation and contains a non-synonymous polymorphism in the major candidate gene Vav1. To formally demonstrate the causal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Central Nervous System
Share to Disease Susceptibility

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Encephalomyelitis, Autoimmune, Experimental

Share to Forkhead Transcription Factors

Share to Proto-Oncogene Proteins c-vav

Share to Receptors, Antigen, T-Cell

Share to T-Lymphocytes, Regulatory

Share to Thymus Gland

Source

Open in PubMed Open full text

Identifiers

PMID: 27438086
DOI: 10.1371/journal.pgen.1006185
PMCID: PMC4954684

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Natural Variant of the T Cell Receptor-Signaling Molecule Vav1 Reduces Both Effector T Cell Functions and Susceptibility to Neuroinflammation.PMID 27438086Read ↗

A role for VAV1 in experimental autoimmune encephalomyelitis and multiple sclerosis.Semantic proximity Read ↗

An Epistatic Interaction between Themis1 and Vav1 Modulates Regulatory T Cell Function and Inflammatory Bowel Disease Development.Semantic proximity Read ↗

Vav1-deficient mice are resistant to MOG-induced experimental autoimmune encephalomyelitis due to impaired antigen priming.Semantic proximity Read ↗

Thymocyte selection in Vav and IRF-1 gene-deficient mice.Semantic proximity Read ↗

TRPV1 gates tissue access and sustains pathogenicity in autoimmune encephalitis.Semantic proximity Read ↗

VAV1 Gene Polymorphisms in Patients with Rheumatoid Arthritis.Semantic proximity Read ↗

Characterization of the spectrum of trivalent VAV1-mutation-driven tumours using a gene-edited mouse model.Semantic proximity Read ↗

Function of the nucleotide exchange activity of vav1 in T cell development and activation.Semantic proximity Read ↗

Kv1.3 deletion biases T cells toward an immunoregulatory phenotype and renders mice resistant to autoimmune encephalomyelitis.Semantic proximity Read ↗

A null mutation in VAMP1/synaptobrevin is associated with neurological defects and prewean mortality in the lethal-wasting mouse mutant.Semantic proximity Read ↗

Caveolin-1 mediates neuroinflammation and cognitive impairment in SARS-CoV-2 infectionSemantic proximity Read ↗

Antigenic Stimulation of Kv1.3-Deficient Th Cells Gives Rise to a Population of Foxp3-Independent T Cells with Suppressive Properties.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.