Article
A role for VAV1 in experimental autoimmune encephalomyelitis and multiple sclerosis.
Science translational medicine - 9 Dec 2009
Jagodic Maja, Colacios Celine, Nohra Rita, Dejean Anne S, Beyeen Amennai Daniel, Khademi Mohsen, Casemayou Audrey, Lamouroux Lucille, Duthoit Christine, Papapietro Olivier, Sjöholm Louise, Bernard Isabelle, Lagrange Dominique, Dahlman Ingrid, Lundmark Frida, Oturai Annette B, Soendergaard Helle B, Kemppinen Anu, Saarela Janna, Tienari Pentti J, Harbo Hanne F, Spurkland Anne, Ramagopalan Sreeram V, Sadovnick Dessa A, Ebers George C, Seddighzadeh Maria, Klareskog Lars, Alfredsson Lars, Padyukov Leonid, Hillert Jan, Clanet Michel, Edan Gilles, Fontaine Bertrand, Fournié Gilbert J, Kockum Ingrid, Saoudi Abdelhadi, Olsson Tomas
Abstract excerpt
Multiple sclerosis, the most common cause of progressive neurological disability in young adults, is a chronic inflammatory disease. There is solid evidence for a genetic influence in multiple sclerosis, and deciphering the causative genes could reveal key pathways influencing the disease. A genome region on rat chromosome 9 regulates experimental autoimmune encephalomyelitis, a model for multiple sclerosis....
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