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Article

An Epistatic Interaction between Themis1 and Vav1 Modulates Regulatory T Cell Function and Inflammatory Bowel Disease Development.

Journal of immunology (Baltimore, Md. : 1950) - 15 Aug 2015

Pedros Christophe, Gaud Guillaume, Bernard Isabelle, Kassem Sahar, Chabod Marianne, Lagrange Dominique, Andréoletti Olivier, Dejean Anne S, Lesourne Renaud, Fournié Gilbert J, Saoudi Abdelhadi

Abstract excerpt

The development of inflammatory diseases depends on complex interactions between several genes and various environmental factors. Discovering new genetic risk factors and understanding the mechanisms whereby they influence disease development is of paramount importance. We previously reported that deficiency in Themis1, a new actor of TCR signaling, impairs regulatory T cell (Treg) function and predisposes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Proto-Oncogene Proteins c-vav

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Share to Receptors, Antigen, T-Cell

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PMID: 26163585
DOI: 10.4049/jimmunol.1402562

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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