Article
TRPV1 gates tissue access and sustains pathogenicity in autoimmune encephalitis.
Molecular medicine (Cambridge, Mass.) - 24 Jul 2013
Paltser Geoffrey, Liu Xue Jun, Yantha Jason, Winer Shawn, Tsui Hubert, Wu Ping, Maezawa Yuko, Cahill Lindsay S, Laliberté Christine L, Ramagopalan Sreeram V, DeLuca Gabriele C, Sadovnick A Dessa, Astsaturov Igor, Ebers George C, Henkelman R Mark, Salter Michael W, Dosch H-Michael
Abstract excerpt
Multiple sclerosis (MS) is a chronic progressive, demyelinating condition whose therapeutic needs are unmet, and whose pathoetiology is elusive. We report that transient receptor potential vanilloid-1 (TRPV1) expressed in a major sensory neuron subset, controls severity and progression of experim...
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