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Article

Next-generation sequencing methylation profiling of subjects with obesity identifies novel gene changes

18 Jul 2016

Abstract excerpt

BACKGROUND: Obesity is a metabolic disease caused by environmental and genetic factors. However, the epigenetic mechanisms of obesity are incompletely understood. The aim of our study was to investigate the role of skeletal muscle DNA methylation in combination with transcriptomic changes in obesity. RESULTS: Muscle biopsies were obtained basally from lean (n = 12; BMI = 23.4 ± 0.7 kg/m(2)) and obese (n = 10; BMI...

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Share to Adipokines, Inflammation, and Metabolic Diseases
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PMID: 27437034
DOI: 10.1186/s13148-016-0246-x

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