25+ Years of TRPV4: From Discovery to Translational Horizons

Abstract excerpt

<title>Abstract</title> <p> Transient receptor potential vanilloid member 4 (TRPV4) is a calcium-permeable, nonselective cation channel first described in 2000. Polymodally-activated, also by osmotic, mechanical, thermal, actinic, and chemical stimuli, TRPV4 has emerged as a versatile molecular integrator across a remarkable diversity of cell lineages and vertebrate organ systems. Re orthology to invertebrate TR...

Topics

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• Gene Expression Regulation
• Genetic Predisposition to Disease
• Membrane Potentials
• Mice, Knockout
• Protein Conformation
• Signal Transduction
• Structure-Activity Relationship
• TRPV Cation Channels

Identifiers and source

Literature Corpus work

7c32a36f-9dd9-5732-a946-ddbdce8a975f

DOI

10.21203/rs.3.rs-10022857/v1