Article
Genetic susceptibility to autoimmune disorders: clues from gene association and gene expression studies.
Current molecular medicine - 1 Sept 2008
Gutierrez-Roelens Ilse, Lauwerys Bernard R
Abstract excerpt
Susceptibility to autoimmune disorders results from the interaction of multiple genetic factors that regulate the threshold of autoreactivity. Genome-wide microsatellite screens and large-scale single nucleotide polymorphism (SNP) association studies have identified chromosomal loci that are associated with specific disorders including systemic lupus erythematosus, rheumatoid arthritis, juvenile arthritis,...
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