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Article

Crotalphine desensitizes TRPA1 ion channels to alleviate inflammatory hyperalgesia.

Pain - 1 Nov 2016

Bressan Elisangela, Touska Filip, Vetter Irina, Kistner Katrin, Kichko Tatjana I, Teixeira Nathália B, Picolo Gisele, Cury Yara, Lewis Richard J, Fischer Michael J M, Zimmermann Katharina, Reeh Peter W

Abstract excerpt

Crotalphine is a structural analogue to a novel analgesic peptide that was first identified in the crude venom from the South American rattlesnake Crotalus durissus terrificus. Although crotalphine's analgesic effect is well established, its direct mechanism of action remains unresolved. The aim of the present study was to investigate the effect of crotalphine on ion channels in peripheral pain pathways. We found...

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Source

Identifiers

PMID: 27434506
DOI: 10.1097/j.pain.0000000000000669

Genes

TRPA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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