N-methylation of a bactericidal compound as a resistance mechanism in Mycobacterium tuberculosis.

doi:10.1073/pnas.1606590113

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Article

N-methylation of a bactericidal compound as a resistance mechanism in Mycobacterium tuberculosis.

Proceedings of the National Academy of Sciences of the United States of America - 2 Aug 2016

Warrier Thulasi, Kapilashrami Kanishk, Argyrou Argyrides, Ioerger Thomas R, Little David, Murphy Kenan C, Nandakumar Madhumitha, Park Suna, Gold Ben, Mi Jianjie, Zhang Tuo, Meiler Eugenia, Rees Mike, Somersan-Karakaya Selin, Porras-De Francisco Esther, Martinez-Hoyos Maria, Burns-Huang Kristin, Roberts Julia, Ling Yan, Rhee Kyu Y, Mendoza-Losana Alfonso, Luo Minkui, Nathan Carl F

Abstract excerpt

The rising incidence of antimicrobial resistance (AMR) makes it imperative to understand the underlying mechanisms. Mycobacterium tuberculosis (Mtb) is the single leading cause of death from a bacterial pathogen and estimated to be the leading cause of death from AMR. A pyrido-benzimidazole, 14, was reported to have potent bactericidal activity against Mtb. Here, we isolated multiple Mtb clones resistant to 14....

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PMID: 27432954
DOI: 10.1073/pnas.1606590113
PMCID: PMC4978242

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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