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C25-modified rifamycin derivatives with improved activity against Mycobacterium abscessus

9 Aug 2022

Abstract excerpt

Abstract Infections caused by Mycobacterium abscessus are difficult to treat due to its intrinsic resistance to most antibiotics. Formation of biofilms and the capacity of M. abscessus to survive inside host phagocytes further complicate eradication. Herein, we explored whether addition of a carbamate-linked group at the C25 position of rifamycin SV blocks enzymatic inactivation by ArrMab, an...

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PMID: 36714853
DOI: 10.1093/pnasnexus/pgac130

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