Article
A single nucleotide polymorphism in hsa‑miR‑146a is responsible for the development of bronchial hyperresponsiveness in response to intubation during general anesthesia.
Molecular medicine reports - 1 Sept 2016
Luan Yong, Li Dongjiang, Gao Lulu, Xie Sha, Pei Ling
Abstract excerpt
Bronchial hyperresponsiveness (BHR) is the most common clinical manifestation identified in asthmatic patients, and intubation is the major factor that stimulates the airway of patients receiving general anesthetic. In the present study, nitric oxide synthase 1 (NOS1) was identified as a target gene of micro (mi)R‑146a using in silico analysis and luciferase assay. Furthermore, the regulatory role of miR‑146a was...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.