Article
Association of the miR-196a2, miR-146a, and miR-499 Polymorphisms with Asthma Phenotypes in a Korean Population.
Molecular diagnosis & therapy - 1 Oct 2017
Trinh Hoang Kim Tu, Pham Duy Le, Kim Su-Chin, Kim Ri-Yeon, Park Hae-Sim, Kim Seung-Hyun
Abstract excerpt
BACKGROUND: MicroRNAs (miRNAs) modulate expressions of inflammatory genes, thereby regulating inflammatory responses. Single nucleotide polymorphisms (SNPs) in miRNAs could affect their efficiency in binding to messenger RNAs (mRNAs). OBJECTIVE: We investigated the associations of miRNA SNPs with asthma phenotypes. miR-196a2 (rs11614913 T>C), miR-146a (rs2910164 C>G), and miR-499 (rs3746444 A>G) were genotyped in...
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