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Article

Allosteric activator domain of maintenance human DNA (cytosine-5) methyltransferase and its role in methylation spreading.

Biochemistry - 13 May 2003

Pradhan Sriharsa, Estève Pierre-Olivier

Abstract excerpt

The human maintenance DNA (cytosine-5) methyltransferase (hDNMT1) consists of a large N-terminal regulatory domain fused to a catalytic C-terminal domain by randomly repeated Gly-Lys dipeptides. Several N-terminal deletion mutants of hDNMT1 were made, purified, and tested for substrate specificity. Deletion mutants lacking 121, 501, 540, or 580 amino acids from the N-terminus still functioned as DNA...

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Identifiers

PMID: 12731873
DOI: 10.1021/bi034160+

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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