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Article

p53 binds human telomeric G-quadruplex in vitro.

Biochimie - 1 Jan 2000

Adámik Matej, Kejnovská Iva, Bažantová Pavla, Petr Marek, Renčiuk Daniel, Vorlíčková Michaela, Brázdová Marie

Abstract excerpt

The tumor suppressor protein p53 is a key factor in genome stability and one of the most studied of DNA binding proteins. This is the first study on the interaction of wild-type p53 with guanine quadruplexes formed by the human telomere sequence. Using electromobility shift assay and ELISA, we show that p53 binding to telomeric G-quadruplexes increases with the number of telomeric repeats. Further, p53 strongly...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27422117
DOI: 10.1016/j.biochi.2016.07.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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