Article
A novel optical biosensor format for the detection of clinically relevant TP53 mutations.
Biosensors & bioelectronics - 15 May 2005
Wilson P K, Jiang T, Minunni M E, Turner A P F, Mascini M
Abstract excerpt
The TP53 gene has been the subject of intense research since the realisation that inactivation of this gene is common to most cancer types. Numerous publications have linked TP53 mutations in general or at specific locations to patient prognosis and therapy response. The findings of many studies using general approaches such as immunohistochemistry or sequencing are contradictory. However, the detection of...
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