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Recent Progress and Future Potential for Metal Complexes as Anticancer Drugs Targeting G-quadruplex DNA

31 May 2012

Abstract excerpt

Now cisplatin and its analogs are some of the most effective chemotherapeutic agents in clinical use as the first line of treatment in testicular and ovarian cancers. Unfortunately, they have several major drawbacks, such as cumulative toxicities of nephrotoxicity and ototoxicity, inherent or treatment-induced resistance. This has provided the motivation for developing novel metal complexes as anticancer agents...

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Share to Advanced biosensing and bioanalysis techniques
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 22519400
DOI: 10.2174/092986712800672067

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