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Article

Electrocatalytic monitoring of metal binding and mutation-induced conformational changes in p53 at picomole level.

Journal of the American Chemical Society - 11 May 2011

Paleček Emil, Ostatná Veronika, Černocká Hana, Joerger Andreas C, Fersht Alan R

Abstract excerpt

We developed an innovative electrochemical method for monitoring conformational transitions in proteins using constant current chronopotentiometric stripping (CPS) with dithiothreitol-modified mercury electrodes. The method was applied to study the effect of oncogenic mutations on the DNA-binding domain of the tumor suppressor p53. The CPS responses of wild-type and mutant p53 showed excellent correlation with...

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PMID: 21491862
DOI: 10.1021/ja201006s

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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