Article
A Longitudinal HbA1c Model Elucidates Genes Linked to Disease Progression on Metformin.
Clinical pharmacology and therapeutics - 1 Nov 2016
Goswami S, Yee S W, Xu F, Sridhar S B, Mosley J D, Takahashi A, Kubo M, Maeda S, Davis R L, Roden D M, Hedderson M M, Giacomini K M, Savic R M
Abstract excerpt
One-third of type-2 diabetic patients respond poorly to metformin. Despite extensive research, the impact of genetic and nongenetic factors on long-term outcome is unknown. In this study we combine nonlinear mixed effect modeling with computational genetic methodologies to identify predictors of long-term response. In all, 1,056 patients contributed their genetic, demographic, and long-term HbA1c data. The top...
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