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Article

Heritability of variation in glycaemic response to metformin: a genome-wide complex trait analysis.

The lancet. Diabetes & endocrinology - 1 Jun 2014

Zhou Kaixin, Donnelly Louise, Yang Jian, Li Miaoxin, Deshmukh Harshal, Van Zuydam Natalie, Ahlqvist Emma, Spencer Chris C, Groop Leif, Morris Andrew D, Colhoun Helen M, Sham Pak C, McCarthy Mark I, Palmer Colin N A, Pearson Ewan R

Abstract excerpt

BACKGROUND: Metformin is a first-line oral agent used in the treatment of type 2 diabetes, but glycaemic response to this drug is highly variable. Understanding the genetic contribution to metformin response might increase the possibility of personalising metformin treatment. We aimed to establish the heritability of glycaemic response to metformin using the genome-wide complex trait analysis (GCTA) method....

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Share to Blood Glucose
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Data Interpretation, Statistical

Share to Diabetes Mellitus, Type 2

Share to Hypoglycemic Agents

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Share to Quantitative Trait, Heritable

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Source

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Identifiers

PMID: 24731673
DOI: 10.1016/S2213-8587(14)70050-6
PMCID: PMC4038749

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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