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Article

Comparative genetic and physiological studies of the MAP kinase Mpk1p from Kluyveromyces lactis and Saccharomyces cerevisiae.

Journal of molecular biology - 21 Jul 2000

Kirchrath L, Lorberg A, Schmitz H P, Gengenbacher U, Heinisch J J

Abstract excerpt

MAP kinases are essential components of signal transduction pathways in yeasts and higher eukaryotes. Here, we report on the isolation of the gene encoding the MAP kinase KlMpk1p by complementation of the respective Saccharomyces cerevisiae deletion mutant with a genomic library from Kluyveromyces lactis. Sequencing revealed the presence of an open reading frame capable of encoding a protein of 520 amino acid...

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PMID: 10891267
DOI: 10.1006/jmbi.2000.3916

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