Article
A yeast mitogen-activated protein kinase homolog (Mpk1p) mediates signalling by protein kinase C.
Molecular and cellular biology - 1 May 1993
Lee K S, Irie K, Gotoh Y, Watanabe Y, Araki H, Nishida E, Matsumoto K, Levin D E
Abstract excerpt
Mitogen-activated protein (MAP) kinases are activated in response to a variety of stimuli through a protein kinase cascade that results in their phosphorylation on tyrosine and threonine residues. The molecular nature of this cascade is just beginning to emerge. Here we report the isolation of a Saccharomyces cerevisiae gene encoding a functional analog of mammalian MAP kinases, designated MPK1 (for MAP kinase)....
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