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Article

LAMPLINK: detection of statistically significant SNP combinations from GWAS data.

Bioinformatics (Oxford, England) - 15 Nov 2016

Terada Aika, Yamada Ryo, Tsuda Koji, Sese Jun

Abstract excerpt

One of the major issues in genome-wide association studies is to solve the missing heritability problem. While considering epistatic interactions among multiple SNPs may contribute to solving this problem, existing software cannot detect statistically significant high-order interactions. We propose software named LAMPLINK, which employs a cutting-edge method to enumerate statistically significant SNP combinations...

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PMID: 27412093
DOI: 10.1093/bioinformatics/btw418
PMCID: PMC5181558

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