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Article

Identification of epistatic SNP combinations in rheumatoid arthritis using LAMPLINK and Japanese cohorts.

Journal of human genetics - 1 Oct 2024

Shibata Mio, Terada Aika, Kawaguchi Takahisa, Kamatani Yoichiro, Okada Daigo, Nagashima Kazuhisa, Ohmura Koichiro, Matsuda Fumihiko, Kawaguchi Shuji, Sese Jun, Yamada Ryo

Abstract excerpt

Genome-wide association studies have enabled the identification of important genetic factors in many trait studies. However, only a fraction of the heritability can be explained by known genetic factors, even in the most common diseases. Genetic loci combinations, or epistatic contributions expressed by combinations of single nucleotide polymorphisms (SNPs), have been argued to be one of the critical factors...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39014190
DOI: 10.1038/s10038-024-01269-y

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