Article

C12ORF57: a novel principal regulator of synaptic AMPA currents and excitatory neuronal homeostasis

2025-01-10

Abstract excerpt

<h4>Objective</h4> Excitatory neuronal homeostasis is crucial for neuronal survival, circuit function, and plasticity. Disruptions in this form of homeostasis are believed to underpin a variety of neuronal conditions including intellectual disability, epilepsy, and autism. However, the underlying genetic and molecular mechanisms maintaining this homeostasis remain poorly understood. Biallelic recurrent loss of fu...

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Literature Corpus work: 8d4aa57d-1cb2-5b18-85b0-2747c90e2910
DOI: 10.1101/2025.01.08.632037

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