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Article

Pigment epithelium-derived factor may induce antidepressant phenotypes in mice by the prefrontal cortex.

Neuroscience letters - 6 Feb 2022

Bai Mengge, Yu Heming, Chen Chong, Xu Xingzhe, He Yong, Wang Yue, Tian Yu, Wu Zhonghao, Lan Tianlan, Li Yan, Chen Xiangyu, Chen Zhi, Zhao Libo, Fang Liang, Yang Deyu, Cheng Ke, Xie Peng

Abstract excerpt

Pigment epithelium-derived factor (PEDF) is a multifunctional glycoprotein encoded by SERPINF1 and our previous study reported that PEDF may have antidepressant effects. As a key brain region regulating cognition, memory and emotion, the prefrontal cortex (PFC) has been studied extensively in major depressive disorder (MDD), but there are few reports on the relationship between PEDF and the PFC. In this study,...

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Identifiers

PMID: 34965441
DOI: 10.1016/j.neulet.2021.136423

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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